Sividon Diagnostics GmbH
Breast cancer: Gene expression test EndoPredict predicts local recurrences
The gene expression test EndoPredict(R) not only determines the probability of metastases of breast cancer, but also describes the risk of a local recurrence in the breast. This is the result of an analysis of the ABCSG-8 study of the Austrian Breast and Colorectal Cancer Study Group. The results were recently published in the British Journal of Cancer.
1324 patients with hormone receptor positive/HER2-negative breast cancer were assigned to a low- or to a high-risk group using the EndoPredict test. A retrospective analysis of the disease courses over a period of ten years demonstrated that 97.5% of the low-risk patients remained free from local recurrences. In high-risk patients, the survival without local recurrences was only 91%. “The knowledge about the increased risk of local recurrence of breast cancer is particularly relevant for follow-up care”, explained Univ.-Prof. Dr. Florian Fitzal, author of the publication , head of the Breast Health Centre in Linz (AUT) and member of the Cancer Comprehensive Center of Vienna Medical University. “Irrespective of the risk of local recurrence, the best local therapy is either a mastectomy or breast-conserving surgery with subsequent radiation.” EndoPredict measures the activity of altogether eight disease-relevant genes. The test is used in routine medical practice to clarify whether a patient requires chemotherapy, or whether this burdensome therapy can be foregone due to the patient’s low risk of recurrence. The test is recommended, amongst others, in the guidelines of the Association of Gynaecological Oncology (AGO) and by the experts of the St. Gallen consensus conference. Sividon Diagnostics GmbH was founded in July 2010 as a management buyout from Siemens Healthcare Diagnostics Products in Cologne, Germany. The company aims to sustainably increase the quality of therapy-accompanying diagnostics in oncology. EndoPredict(R), the first diagnostic test from Sividon, has been available since 2011. Further information is available at www.sividon.com or www.endopredict.com.
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